Law enforcement and other first responders are on the front lines of addressing illicit substance use and misuse, responding to frequent drug overdoses and calls for services involving individuals with substance use and misuse and co-occurring disorders. A variety of multidisciplinary law enforcement and first-responder models have emerged in communities throughout the nation that reduce and prevent overdoses and connect individuals to treatment services and recovery supports. These models often include first responders working in partnership with behavioral health treatment providers and peer recovery coaches to co-respond to incidents or for post-overdose follow-up and connection to comprehensive, evidence-based substance use and misuse treatment services.