This publication is intended to add to some of the information (e.g., pharmacological approaches) currently found in the Substance Abuse and Mental Health Services Administration (SAMHSA) Treatment Improvement Protocol (TIP) 51, Substance Abuse Treatment: Addressing the Specific Needs of Women. It offers guidance to providers and administrators about the particular needs of women during substance use disorder treatment. It summarizes key messages, recommendations for screening and assessment, gender-focused approaches to treatment and support, and considerations for women in specific racial/ethnic populations.