The purpose of this publication is to analyze current public health campaigns that address the stigma of substance use disorder (SUD). Historically, public health campaigns were often designed to instill a fear of substances; campaigns meant to specifically decrease the stigma of SUD and those seeking treatment for SUD are a much more recent development. While stigma is not an issue that will be beat with public health campaigns alone, the switch from fear-mongering anti-tobacco campaigns of the 1960s to more educational and empathetic campaigns of today is worth examining.