Overdose Fatality Review (OFR) is a nationally recognized model used by a growing number of communities to strengthen their community-based responses to the opioid overdose epidemic. The goal of this OFR guide is to provide the reader with the needed information to build a successful OFR process with a strong foundation in coalition, data collection, and prevention. The OFR guide content draws on other fatality reviews and the authors’ practice-based knowledge. It is organized into five modules: Recruit Your OFR Team, Plan Your OFR Team, Facilitate Your OFR Team, Collect Your OFR Data, Build a Recommendation Plan.