In this plenary session, highlights the work of Knox County, Tennessee. They established its overdose fatality review (OFR) team in 2021, and as of October 2022, the team had reviewed 105 cases. In its first annual report, the OFR team identified hospital emergency departments (EDs) as a high-priority setting for substance misuse interventions and overdose prevention. This session identifies at least one evidence-based model for connecting individuals with substance use disorder to treatment.