In 2002, Congress appropriated funds for implementation and enhancement of prescription drug monitoring programs (PDMPs) through the Harold Rogers PDMP Grant Program. The grant funding supported states in implementing PDMPs, with an increase in the number of PDMPs from 16 (2002) to 54 (2020). The dramatic increase in PDMPs led to the realization that there was a need for interstate data sharing. BJA appropriated funds that allowed PDMPs to develop and implement an interstate data sharing solution. The RxCheck Hub fulfills that need and also allows the integration of PDMP data with electronic health records. This document provides an overview of the integration process for the RxCheck Hub.