The projects described herein are a sampling of the various ways in which EMS, particularly state EMS offices, have approached the challenges of opioids and substance use disorders. The examples detailed in the article are not meant to be all-inclusive of the variety of efforts undertaken nationwide. The projects are grouped under the following categories:

• Naloxone Leave Behind Programs
• EMS Data for Surveillance and Response
• Community Paramedic and Medication-assisted Treatment Programs
• Training and Support for EMS Providers
• Statewide Overdose System of Care