While the Medication-Assisted Treatment for Opioid Use Disorder Playbook (referred to as the MAT for OUD Playbook) aims to help providers in rural primary care, the information in the playbook should apply to other ambulatory care settings. This interactive, web-based product has the latest guidance, tools, and resources that address key aspects of implementation. The MAT for OUD Playbook aims to address the growing need for guidance as more primary care practices and health systems begin to implement MAT. The playbook’s framework is designed to be useful for practices implementing any array of MAT services.