The Integration Framework provides guidance to health care systems, states, and health information technology (IT) vendors to support successful project execution, management and communications for Health IT integrations. The Integration Framework draws on experience with PDMP-EHR integration and electronic CDS. The phases, process steps, and practices presented in this Framework may be applicable to other health IT projects. The Framework includes two separate sections that provide specific guidance for PDMP-EHR Integration and electronic Clinical Decision Support implementation.