The opioid epidemic is an ongoing problem in rural areas. Rural youth, young adults, women experiencing domestic violence, and people living in states with large rural populations suffer from higher rates of opioid use than their urban counterparts. Opioid overdose deaths are growing faster in rural counties than urban counties. This presentation by John Gale, MS, of the University of Southern Maine focuses on a wide range of strategies that communities can use to combat the opioid problem. In particular, it discusses cost-effective, evidence-based prevention, treatment, and recovery programs that have been successfully implemented in rural communities. It concludes by describing community organizing strategies to engage a wide range of local stakeholders to reduce the burden of opioid use.