This workshop will feature discussion from tribal representatives on their responses to drug use and overdose in their communities. Topics will include the development of multidisciplinary governance structures to guide the decision making; pulling together multiple streams of information across agencies; using tools such as the Overdose Detection Mapping Application Program (ODMAP) and overdose fatality review (OFR) to better understand the nature of drug use; and creating active partnerships between public health and public safety to intervene with individuals at risk for overdose.