The United States remains in the midst of an unprecedented overdose epidemic, with more than 100,000 overdose deaths in the year ending April 2021. The vast majority of these overdose deaths are opioid-related and could have been averted had naloxone been administered by those present. Naloxone is one of the most powerful tools communities have in combating the overdose crisis; evidence shows that distribution can reduce overdose deaths. Jails have emerged as a critical overdose prevention touchpoint.