This Advisory provides guidance on identifying and addressing suicidal thoughts and behaviors among individuals with SUD. It is based on SAMHSA’s Treatment Improvement Protocol (TIP) 50, Addressing Suicidal Thoughts and Behaviors in Substance Abuse Treatment. It summarizes key messages, promotes use of the Zero Suicide framework, part of the Surgeon General’s national strategy for suicide prevention, and provides additional resources for substance use clinicians and program administrators regarding the treatment of clients with suicidal thoughts and behaviors in SUD treatment settings.