It is organized as a technical assistance resource and guide for creating similar initiatives in other cities and counties around the United States. This manual is informed by the first two years of experience with RxStat in New York City, where the initiative was established in 2012. The initiative relies on the collaboration of public health and public safety agencies in a jurisdiction. RxStat incorporates data from local, state, and federal government sources and applies a public health analysis for comparing and triangulating findings across datasets. These efforts require an investment in data analysts to conduct the work, and a willingness among agencies to share data for analysis.